MethodsStudy participantsWe enrolled pregnant women between 14 and 32 weeks of gestation at high risk of pre eclampsia who were receiving prenatal care at the Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes in Mexico City between January 2001 and December 2005. We included patients at increased risk of pre eclampsia, which we defined as either a personal history of pre eclampsia or pre eclampsia in a first degree relative. Eligible participants agreed to have their prenatal care and delivery at the institution and provide informed consent.
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